The probably use of MR-spectroscopy and diffusion weighted-MRI of bone marrow for treatment monitoring in patients with chronic lymphatic leukemia

Objectives: To assess the usefulness of proton MR-spectroscopy (1H-MRS) and diffusion-weighted MRI (DW-MRI) sequences in follow-up CLL-patients with chemotherapy treatment. The monitoring susceptible to treatment is complicated due difficulty assessing response Chemotherapy leads changes bone marrow composition these can be evaluated by functional MR-sequences. Methods: 23 patients diagnosed CLL our hospital’s Hematology Service underwent a lumbar MR prior post-chemotherapy applying 1H-MRS DW-MRI. concentrations water lipids were quantified quantification program LCModel. Apparent Diffusion Coefficient (ADC) values calculated Functool (GE). Wilcoxon sign test was used compare pre post results, considering statistically significant P lower than 0.05. Results: Responder decreased ratio H2O/lipids concentration measured increased ADC value on DW-MRI post-treatment studies (P<0.05). Patients without or did not modify data. Conclusion: spinal are non-invasive repeatable techniques that might help CLL.